Lomustine (patient information)

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Lomustine can cause a decrease in the number of blood cells in your bone marrow. Your doctor will order tests before, during, and after your treatment to see if your blood cells are affected by this drug.

About your treatment

Your doctor has ordered the drug lomustine to help treat your illness. The drug is taken by mouth in capsule form. Your full dose may contain two or more different types of capsules. Take all of them at the same time, with fluids, on an empty stomach. Lomustine usually is given once every 6 weeks.

This medication is used to treat:

  • brain tumors
  • Hodgkin's disease

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Lomustine is in a class of drugs known as alkylating agents; it slows or stops the growth of cancer cells in your body. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.

Other uses for this medicine

Lomustine is also used in the treatment of bronchogenic carcinoma, non-Hodgkin's lymphomas, malignant melanoma, breast cancer, renal cell carcinoma, and carcinoma of the GI tract. Lomustine has been applied to the skin to treast mycosis fungoides and psoriasis. Talk to your doctor about the possible risks of using this drug for your condition.


Before taking lomustine:

  • tell your doctor and pharmacist if you are allergic to lomustine or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially aspirin and vitamins.
  • you should know that lomustine may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. However, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breast-feeding should tell their doctors before they begin taking this drug. You should not plan to have children while receiving chemotherapy or for a while after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy. Lomustine may harm the fetus.
  • do not have any vaccinations (e.g., measles or flu shots) without talking to your doctor.
  • be aware that lomustine has been associated with the development of other types of cancers. *Talk with your doctor about the potential risk of developing a new cancer.

Side effects

Minor side effects

Side effects from lomustine are common and include:

  • darkened and dry skin
  • loss of appetite or weight
  • weakness

Tell your doctor if the following symptom is severe or lasts for several hours:

  • fatigue

Severe side effects

If you experience any of the following symptoms, call your doctor immediately:

  • unusual bruising or bleeding
  • black, tarry stools
  • red urine
  • cough
  • sore throat
  • difficulty breathing
  • fever
  • dizziness
  • confusion
  • chills
  • shortness of breath
  • rash
  • yellowing of the skin or eyes

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088].

Storage conditions

Keep lomustine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Brand names

  • CeeNU®
  • CeeNU®Dose Pack

Other names

  • CCNU