Epidermodysplasia verruciformis

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Epidermodysplasia verruciformis
OMIM 226400 305350
DiseasesDB 31394
eMedicine derm/123 

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]


Epidermodysplasia verruciformis (also called Lewandowsky-Lulz dysplasia or Lulz-Lewandowsky epidermodysplasia verruciformis) is an extremely rare skin disease characterized by the growth of scaly macules and papules, particularly on the hands. Named after doctors Felix Lewandowsky and Wilhelm Lulz,[1] the condition usually begins in childhood and has no known cure.

It is believed to be caused by the human papillomavirus and is most strongly associated with strains 5 and 8, although others may also contribute. Genetic predisposition is also thought to partly explain why the disease is so rare, as EV papillomaviruses are often found (15-20%) in normal skin with no increased incidence of cancer.


Physical Examination



Notable cases

In March 2007, a Romanian man was diagnosed with this condition. The man, patient of dermatologist Dr. Carmen Madeleine Curea, quickly became an internet meme, his pictures appearing on numerous blogs[3] and Romanian press sources.[4] Dr. Curea works out of Spitalului Clinic Colentina in Bucharest, Romania.[5] Stephen Stone, past president of the American Academy of Dermatology, confirms this is Lewandowsky-Lutz.[6]

Further reading

  • H. Sadakane, Y. Yabe. The Virus of Epidermodysplasia Verruciformis: Electron Microscopic and Fluorescent Antibody Studies. Journal of Investigative Dermatology (1975) 65, 324–330 [3]
  • F. Lewandowsky, W. Lulz. Ein Fall einer bisher noch nicht beschriebener Hauterkrankung (Epidermodysplasia verruciformis). Archiv für Dermatologie und Syphilis (1922) 141, 193-202.


  1. Lewandowsky-Lulz dysplasia: Who Named It?
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Dermatology Atlas".
  3. http://www.markallencam.com/?p=155
  4. http://petricapatilea.directnews.ro/2007/03/13/cernobal-inca-loveste/ Cernobal inca loveste!
  5. http://www.sisnet.ro/index.php?page=articol&id=14684
  6. http://www.revolutionhealth.com/blogs/valjonesmd/rare-skin-disorder-ma-2928 Rare skin disorder may be triggered by wart virus?

External links

nl:Lewandowsky-Lutz dysplasie

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